Welcome to eClinPath, an online textbook on Veterinary Clinical Pathology
The goal of this site is to be an educational resource on veterinary clinical pathology – an “on-line” textbook as it were. We hope this will be a valuable resource, as are the several available paper textbooks on this discipline. We continually strive to update and modify the site and appreciate your feedback. Below under each section, we have added an update list. We will only use this major updates and changes, not minor things such as an addition or correction here or there, addition of a reference etc.
Note that as we add new pages, we will be providing references (with links to PubMed etc – we have provided a list of references used to create the initial site below) and as we update our old pages, we will also strive to add references to those (this will be a long term slow project, but bear with us).
Follow us on twitter for updates, alerts re case of the month or info on articles we have just read: @eClinPathCU or Clin Path at Cornell. Like us on Facebook (Clinical Pathology at Cornell University) or follow us on Instagram account (eclinpath_cornell)…linked them all to the best of our ability….
The site is organized into sections as indicated by the tabs and top navigation bar (calculations, case of the month). Each section provides detailed information on related topics and is continually updated so keep checking (and stay tuned for more). All the information from our old site is here, much of which has been updated (those sections that are not updated will be in due course). Some sections have new information (e.g. test basics) but are still not to the point where we wish them to be. Our clinical pathology data calculators, cytology and exotics pages are definitely works in progress.
Please note, that everything on this site is subject to copyright under a Creative Commons license. If you wish to cite us, refer to the about us page.
- Atlas: This is a quick reference guide that provides various clinical pathologic images, including hematology (e.g. normal leukocytes and erythrocytes by species), urine sediment examination (e.g. crystals, cells), and cytology. We plan to add a lot more, so stay tuned. This section of the site is currently not searchable using the generic search tool, but this will change.
- Update on bone marrow atlas:
- Have now added non-neoplastic marrows (including histologic images), dysplastic marrows, acute leukemia, chronic leukemia, lymphoma and other neoplasia galleries, but few images as yet (March 2017 and January 2018)
- Update on cytology atlas:
- Started on endocrine/neuroendocrine tumors (Nov 2017)
- Started on glandular tissue (Nov 2017)
- Started on a nasal cavity album (Nov 2017)
- Started on a dog/cat pleural fluid album (Nov 2017)
- Started on a gastrointestinal tract album (Dec 2017)
- Started on a pancreas album (Dec 2017)
- Started on an eye album (Dec 2017)
- Started on a kidney album (Dec 2017)
- Added more images to the equine peritoneal fluid album (August 2018)
- Small mammals atlas:
- Exotic atlas:
- Update on bone marrow atlas:
- Case of the month: Challenge yourself with classic and interesting cases we have seen at Cornell University. Search our index for old cases! As for the Atlas, this section is currently not searchable through the generic search tool.
- Calculations: This takes you to conversion formula (standard international to conventional units) and other clinical pathologic-related calculations, e.g. red blood cell indices (e.g. mean cell volume), reticulocyte counts (e.g. absolute reticulocyte count), fractional excretion of electrolytes (e.g. sodium). Under construction.
- Test basics: Information on reference intervals, non-disease variables that impact test results (e.g. hemolysis, lipemia, icterus, including a table that summarizes common artifacts seen with laboratory tests). We plan to add sections on quality control concepts (accuracy, precision, bias) and statistical concepts important to clinical pathology (e.g. sensitivity, specificity).
- Hematology: Information on all aspects of hematology and is organized into sections based on cell types in blood (leukocytes, erythrocytes and platelets). See also the Atlas for image compilations.
- Update: Added information on erythrocyte physiology and general hematopoiesis (May 2017).
- Update: Updated the page on Cytauxzoon.
- Update: Leukemia pages with new algorithms (May 2017), which use the new term lymphoma with a leukemic phase. Still need to write a page (with updates) on myelodysplastic syndromes.
- Hemostasis: Information on the physiology of hemostasis, clinical signs, diagnostic testing (including sample collection), hemostatic disorders and transfusion medicine.
- Urinalysis: Information on urine production and urine components (chemicals, cells, casts, crystals). See also the Atlas for image compilations.
- Chemistry: Information on sample collection, chemistry analytes (provided on most biochemical panels), techniques used to measure variables (e.g. potentiometry, electrophoresis) and organ function.
- Update: Added a page on vitamin D (June 2017).
- Update: Modified our information on interferences and interpretation of chemistry indices of turbidity (used to be called lipemia), hemolysis and icterus that are provided with our biochemistry results. These are now based on our new chemistry analyzer, the Cobas 501 (January 2018).
- Update: Moved bicarbonate and anion gap to a new page on chemistry tests for acid-base disturbances (February 2018).
- Cytology: Information on sample collection and expected cytologic findings with different processes. See also the atlas for image compilations. Under construction.
- Exotics: Clinical pathologic testing of exotic animal species (reptiles, amphibians, small mammals). Under construction.
We are striving to add primary literature references to all sections of this website. This will be done as we modify and update pages and will be done with all new pages. When this site was created, it was for the sole purpose of providing students in the College of Veterinary Medicine at Cornell University to supplement the new (at the time, in 1999) problem-based curriculum. At that time, there were few textbooks available on veterinary clinical pathology (now there are a plethora). So the original content was based on information in these available textbooks:
- Clinical Pathology book: An internal resource generated by Drs. Julia Blue and Tracy French.
- Tietz: Textbook of Clinical Chemistry, third edition.
- Duncan and Prasse: Fundamentals of Veterinary Clinical Pathology (first edition).
- Kaneko: Clinical Biochemistry of Domestic Animals (first edition).
- Jain: Essentials of Veterinary Hematology
- Schalm’s: Veterinary Hematology (the old yellow original one, still a favorite)
- Osborne: Urinalysis: A Clinical Guide to Compassionate Patient Care
More recently, we have, of course, used:
- Stockham and Scott: Fundamentals of Veterinary Clinical Pathology